Volume 2 - Issue 1, January - February 2026

The present study aimed to compare the clinical outcomes of Intracytoplasmic Sperm Injection (ICSI) and Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) in infertile couples undergoing assisted reproductive treatment. A total of 100 couples treated at Nova IVF Fertility Clinic, Chandigarh, and equally allocated into two groups: ICSI (n = 50) and IMSI (n = 50). Demographic characteristics and semen parameters were assessed, along with IVF failure history, embryo quality, implantation rate, clinical pregnancy rate, and miscarriage rate. Other variables, including male age, sperm concentration, and motility, were comparable between the two groups. IMSI demonstrated significantly improved sperm morphology compared to ICSI (p < 0.001), with a corresponding reduction in abnormal sperm forms. The IMSI group showed a significantly higher proportion of Grade A embryos and a higher clinical pregnancy rate (86% vs. 64%). Implantation rates were higher in the IMSI group, though the difference was not statistically significant. The frequency of repeated IVF failures was significantly lower in the IMSI group (χ² = 8.23, p = 0.016). Miscarriage rates were lower following IMSI; however, this difference did not reach statistical significance. In conclusion, IMSI appears to improve sperm selection, embryo quality, and pregnancy outcomes compared to conventional ICSI, particularly in selected cases of male factor infertility and first IVF cycles. Larger multicentric studies evaluating live birth outcomes are warranted to confirm these findings.

Vikas Dhyani, Veerpal Kaur, Bhupinderjit Kaur Heer,"Comparative Analysis of Clinical Outcome of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) and Intracytoplasmic Sperm Injection (ICSI)" International Journal of Scientific Research and Engineering Development, V2(1): Page(270-273) Jan-Feb 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.