Peer Reviewed Open Access Journal
Volume 2 - Issue 1, January - February 2026
📑 Paper Information
| 📑 Paper Title | Effectiveness of Constitutional Homoeopathic Medicines in Alzheimer’s Disease with Aided Cognitive Therapy: A Randomised Placebo-Controlled Trial |
| 👤 Authors | Dr.Shivani Sharma, Dr.Pranab Kumar Chakarborty, Dr.Shalu Munjal |
| 📘 Published Issue | Volume 2 Issue 1 |
| 📅 Year of Publication | 2026 |
| 🆔 Unique Identification Number | IJAMRED-V2I1P232 |
| 📑 Search on Google | Click Here |
📝 Abstract
Background
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder and the most common cause of dementia globally. Despite advances in pharmacotherapy, currently available medications offer only modest symptomatic benefit and do not substantially alter disease progression. There remains a need for integrative and individualized therapeutic strategies. Homoeopathy, grounded in constitutional and holistic principles, aims to address cognitive, emotional, and behavioural dimensions of disease. Structured supportive interventions inspired by cognitive–behavioural therapy (CBT) may further enhance cognitive engagement and orientation. This study assessed the effectiveness of individualized constitutional Homoeopathic treatment combined with aided cognitive–behavioural supportive therapy in improving cognitive outcomes in patients with Alzheimer’s disease using the ADAS-Cog scale.
Methods
A randomized, placebo-controlled trial was conducted involving 80 screened patients, of whom 68 met eligibility criteria and were enrolled. Participants were randomly assigned to:
• Homoeopathic Medicine Group (n = 34)
• Placebo Group (n = 34)
The intervention group received individualized constitutional prescriptions based on totality of symptoms, miasmatic assessment, and repertorial analysis. Both groups received standardized aided therapy including orientation cues, structured routine reinforcement, and memory-engagement tasks. Cognitive performance was evaluated using the ADAS-Cog scale at baseline and after 3 months. Statistical analysis included paired t-tests for within-group comparison and independent t-tests with Welch’s correction for between-group comparison. Significance level was set at p < 0.05.
Results
The Homoeopathic group demonstrated a statistically highly significant reduction in ADAS-Cog scores (mean difference 4.79 ± 1.01; t = 27.72; p < 0.0001). The placebo group showed no statistically significant change (mean difference 0.24 ± 1.35; t = 1.02; p = 0.317). Between-group comparison confirmed superiority of Homoeopathic treatment (t = 15.74; p < 0.00001). The effect size (Cohen’s d = 3.82) indicated an extremely large clinical effect.
Conclusion
Individualized constitutional Homoeopathic treatment combined with aided cognitive support produced statistically significant and clinically meaningful cognitive improvement in Alzheimer’s patients compared to placebo. These findings suggest a potential role for integrative supportive approaches in dementia care. Larger multi-centre trials with extended follow-up are recommended.
Alzheimer’s disease (AD) is a chronic, progressive neurodegenerative disorder and the most common cause of dementia globally. Despite advances in pharmacotherapy, currently available medications offer only modest symptomatic benefit and do not substantially alter disease progression. There remains a need for integrative and individualized therapeutic strategies. Homoeopathy, grounded in constitutional and holistic principles, aims to address cognitive, emotional, and behavioural dimensions of disease. Structured supportive interventions inspired by cognitive–behavioural therapy (CBT) may further enhance cognitive engagement and orientation. This study assessed the effectiveness of individualized constitutional Homoeopathic treatment combined with aided cognitive–behavioural supportive therapy in improving cognitive outcomes in patients with Alzheimer’s disease using the ADAS-Cog scale.
Methods
A randomized, placebo-controlled trial was conducted involving 80 screened patients, of whom 68 met eligibility criteria and were enrolled. Participants were randomly assigned to:
• Homoeopathic Medicine Group (n = 34)
• Placebo Group (n = 34)
The intervention group received individualized constitutional prescriptions based on totality of symptoms, miasmatic assessment, and repertorial analysis. Both groups received standardized aided therapy including orientation cues, structured routine reinforcement, and memory-engagement tasks. Cognitive performance was evaluated using the ADAS-Cog scale at baseline and after 3 months. Statistical analysis included paired t-tests for within-group comparison and independent t-tests with Welch’s correction for between-group comparison. Significance level was set at p < 0.05.
Results
The Homoeopathic group demonstrated a statistically highly significant reduction in ADAS-Cog scores (mean difference 4.79 ± 1.01; t = 27.72; p < 0.0001). The placebo group showed no statistically significant change (mean difference 0.24 ± 1.35; t = 1.02; p = 0.317). Between-group comparison confirmed superiority of Homoeopathic treatment (t = 15.74; p < 0.00001). The effect size (Cohen’s d = 3.82) indicated an extremely large clinical effect.
Conclusion
Individualized constitutional Homoeopathic treatment combined with aided cognitive support produced statistically significant and clinically meaningful cognitive improvement in Alzheimer’s patients compared to placebo. These findings suggest a potential role for integrative supportive approaches in dementia care. Larger multi-centre trials with extended follow-up are recommended.
📝 How to Cite
Dr.Shivani Sharma, Dr.Pranab Kumar Chakarborty, Dr.Shalu Munjal,"Effectiveness of Constitutional Homoeopathic Medicines in Alzheimer’s Disease with Aided Cognitive Therapy: A Randomised Placebo-Controlled Trial" International Journal of Advanced Multidisciplinary Research and Educational Development, V2(1): Page(1478-1481) Jan-Feb 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.
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