Volume 2 - Issue 1, January - February 2026

Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs. From early beginnings using off-the-shell materials, the field has grown tremendously, driven in part by the innovations of chemical engineers. Modern advances in drug delivery are now predicated upon the rational design of polymers tailored for specific cargo and engineered to exert distinct biological functions. In this review, we highlight the fundamental drug delivery systems and their mathematical foundations and discuss the physiological barriers to drug delivery. We review the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymerprotein and polymer-drug conjugates. The latest developments in polymers capable of molecular recognition or directing intracellular delivery are surveyed to illustrate areas of research advancing the frontiers of drug delivery.Polymers play a vital role in modern drug delivery systems by controlling drug release, enhancing therapeutic efficacy, improving patient compliance, and providing targeted delivery.

Ch.Naga Sowjanya, Dr.D Rama Bramha Reddy, M. Prasanthi,"A Review on Polymers in Pharmaceutical Drug Delivery System" International Journal of Scientific Research and Engineering Development, V2(1): Page(97-105) Jan-Feb 2026. ISSN: 3107-6513. www.ijamred.com. Published by Scientific and Academic Research Publishing.